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原文 | 译文 | 详情 |
---|---|---|
severe asthma | 重症哮喘 | - |
biomarker strategy group | 生物标志物策略组 | - |
corticosteroid dose | 皮质类固醇剂量 | - |
the control group | 对照组 | - |
corticosteroid treatment | 激素疗效 | - |
lung function | 肺功能 | - |
proportion of patients | 患者比例 | - |
personal fees | 个人费用 | - |
treatment advisories | 治疗建议 | - |
beclometasone dipropionate | 二丙酸倍氯米松 | - |
uncontrolled asthma | 无法控制的哮喘 | - |
asthma control | 哮喘控制 | - |
PP analysis | PP分析 | - |
Proportion of patients | 患者比例 | - |
µg equivalent | µg当量 | - |
electronic case-report form | 电子病例报告表 | - |
their corticosteroid treatment | 他们的皮质类固醇治疗 | - |
study visit | 学习访问 | - |
primary outcome | 主要结果 | - |
follow treatment advisories | 遵守治疗建议 | - |
reduce corticosteroid treatment | 减少皮质类固醇治疗 | - |
severe exacerbation | 严重加重 | - |
the ITT population | ITT人口 | - |
treatment advice | 治疗建议 | - |
oral corticosteroids | 口服皮质类固醇 | - |
treatment groups | 治疗组 | - |
advisory boards | 咨询委员会 | - |
study groups | 学习小组 | - |
randomly assigned | 随机分配 | - |
severe exacerbations | 严重恶化 | - |
Refractory Asthma Stratification Programme | 难治性哮喘分层方案 | - |
randomised controlled trial | 随机对照试验 | - |
exacerbation rate | 加重率 | - |
corticosteroid treatment dose | 皮质类固醇治疗剂量 | - |
fractional exhaled nitric oxide | 呼出分数一氧化氮 | - |
reduce treatment | 减少治疗 | - |
quality of life | 生活质量 | - |
Medical Research Council | 医学研究委员会 | - |
Blood eosinophil count | 血嗜酸性粒细胞计数 | - |
asthma symptoms | 哮喘症状 | - |
no significant difference | 无显著性差异 | - |
parallel group | 平行群 | - |
increased risk | 风险增加 | - |
blood eosinophils | 血嗜酸细胞 | - |
serum periostin | 血清骨膜素 | - |
parts per billion | 十亿分比 | - |
odds ratio | 比数比 | - |
study group | 研究小组 | - |
J Respir Crit Care Med | J Respir Crit Care Med | - |
Asthma Control | 哮喘控制 | - |
Asthma Quality of Life Questionnaire | 哮喘生活质量问卷 | - |
treatment group | 处理组 | - |
standard care | 标准护理 | - |
symptom scores | 症状评分 | - |
forced vital capacity | 用力肺活量 | - |
at least one | 至少一个 | - |
severe asthma exacerbation | 严重哮喘加重 | - |
treatment advisory | 治疗咨询 | - |
lower dose | 低剂量 | - |
rate ratio | 速率比 | - |
treatment strategy | 治疗策略 | - |
effect estimate shown | 显示效果估计 | - |
a biomarker-based strategy | 基于生物标志物的策略 | - |
blood eosinophil count | 血嗜酸性粒细胞计数 | - |
number of patients | 病人人数 | - |
biomarker profile | 生物标志物图谱 | - |
Oral corticosteroid dose | 口服皮质类固醇剂量 | - |
hazard ratio | 危险比 | - |
secondary aim | 次要目标 | - |
high-dose treatment | 大剂量治疗 | - |
a significantly greater proportion | 更大的比例 | - |
have been | 目前已 | - |
corticosteroid reduction | 皮质类固醇减量 | - |
Cumulative oral corticosteroid | 累积性口服皮质类固醇 | - |
non-financial support | 非财政支助 | - |
a lower corticosteroid | 低糖皮质激素 | - |
clinical centres | 临床中心 | - |
corticosteroid therapy | 糖皮质激素治疗 | - |
symptomatic patients | 有症状的病人 | - |
the eCRF software | eCRF软件 | - |
study procedures | 研究程序 | - |
adjust corticosteroid dose | 调整皮质类固醇剂量 | - |
biomarker-low patients | 低生物标志物患者 | - |
Biomedical Research Centre | 生物医学研究中心 | - |
secondary outcomes | 次要结果 | - |
systemic corticosteroid | 全身皮质类固醇 | - |
the trial algorithm | 试用算法 | - |
Secondary outcomes | 次要结果 | - |
reduced treatment | 减量处理 | - |
a greater proportion | 更大的比例 | - |
no evidence | 没有证据 | - |
lowest dose | 最低剂量 | - |
recent exacerbation history | 近期病情加重史 | - |
last study visit | 上次访学 | - |
baseline randomisation visit | 基线随机访问 | - |
post-hoc analysis | 事后分析 | - |
adverse events | 不良事件 | - |
Oral corticosteroid use | 口服皮质类固醇使用 | - |
protocol-defined exacerbation | 协议定义的加重 | - |
maintain treatment | 维持治疗 | - |
treatment centre | 治疗中心 | - |
smoking status | 吸烟状态 | - |
a default advisory | 默认通知 | - |
use of rescue | 使用救援 | - |
Inhaled corticosteroid dose | 吸入皮质类固醇剂量 | - |
composite score | 综合得分 | - |
patients reducing | 减少患者 | - |
strategy group | 战略小组 | - |
Odds ratio | 比数比 | - |
control symptoms | 控制症状 | - |
reduce exacerbations | 减少病情恶化 | - |
Time to first exacerbation | 首次加重时间 | - |
last year | 去年 | - |
study entry | 学习条目 | - |
oral corticosteroid | 口服皮质类固醇 | - |
Global Initiative for Asthma | 全球哮喘倡议 | - |
AQLQ total score | AQLQ总分 | - |
inhaled corticosteroid dose | 吸入皮质类固醇剂量 | - |
Asthma Control Questionnaire | 哮喘控制问卷 | - |
a composite biomarker | 复合生物标志物 | - |
patients who had | 例病人 | - |
control group | 对照组 | - |
treatment adjustment | 治疗调整 | - |
inhaled corticosteroid | 吸入性激素 | - |
Control group | 对照组 | - |
Effect estimate | 效果估计 | - |
ill health | 健康欠佳 | - |
Severe Asthma | 重症哮喘 | - |
study visits | 考察访问 | - |
dose of ICS | ICS剂量 | - |
treatment adjusted | 待遇调整 | - |
biomarker strategy | 生物标志物策略 | - |
exhaled nitric oxide | 呼出一氧化氮 | - |
Asthma exacerbations | 哮喘加重 | - |
biomarker-based strategy | 基于生物标志物的策略 | - |
Research Centre | 研究中心 | - |
treatment adjustment | 治疗调整 | - |
blood eosinophil counts | 血液嗜酸性粒细胞计数 | - |
symptomatic patient | 有症状的病人 | - |
treatment adjustments | 待遇调整 | - |
Effect estimate shown | 显示效果估计 | - |
Forced vital capacity | 用力肺活量 | - |
PP) analysis | PP)分析 | - |
Uncontrolled asthma | 无法控制的哮喘 | - |
Biomarker strategy group | 生物标志物策略组 | - |
post-hoc analyses | 事后分析 | - |
dose of corticosteroid | 皮质类固醇剂量 | - |
related ill health | 相关的健康不良 | - |
lower corticosteroid dose | 低剂量皮质类固醇 | - |
reduce corticosteroid treatment | 减少皮质类固醇治疗 | - |
asthma exacerbation | 哮喘加重 | - |
Smoking status | 吸烟状况 | - |
Increased risk | 风险增加 | - |
rescue steroid | 救护类固醇 | - |
A default advisory | 默认通知 | - |
rescue steroids | 救护类固醇 | - |
reduced exacerbations | 减少病情恶化 | - |
Followed treatment adv | 后续治疗 | - |
Advisory Board | 咨询委员会 | - |
Followed treatment advisories | 遵循治疗建议 | - |
treatment strategies | 治疗策略 | - |
secondary outcome | 次要结果 | - |
eosinophil counts | 嗜酸性粒细胞计数 | - |
symptom score | 症状评分 | - |
asthma exacerbations | 哮喘加重 | - |
beclometasone dipropionate | 二丙酸倍氯米松 | - |
反式 | Trans | - |
抑制细胞 | Suppressor cell | - |
OE | OE | - |
Corning | Corning | - |
基因转录 | Gene transcription | - |
细胞因子风暴 | Cytokine storm | - |
磷酸化水平 | Phosphorylation level | - |
成纤维细胞 | Fibroblasts | - |
培养上清 | Culture supernatant | - |
磷酸化 | Phosphorylation | - |
微生物感染 | Microbial infection | - |
实验组 | Experimental group | - |
shRNA病毒 | ShRNA virus | - |
PCR | PCR | - |
冠状病毒 | Coronavirus | - |
自身免疫疾病 | Autoimmune disease | - |
因子检测 | Factor detection | - |
扩增 | Amplification | - |
人上皮细胞 | Human epithelial cell | - |
SuperMix | SuperMix | - |
类风湿性关节炎 | Rheumatoid arthritis | - |
肿瘤免疫治疗 | Tumor immunotherapy | - |
qPCR | QPCR | - |
治疗靶点 | Therapeutic target | - |
培养板 | Culture plate | - |
release | Release | - |
急性炎症 | Acute inflammation | - |
FLS | FLS | - |
puro | Puro | - |
中加入 | Add to | - |
室温 | Room temperature | - |
病毒载体 | Viral vector | - |
冠状病毒肺炎 | Coronavirus pneumonia | - |
DMEM | DMEM | - |
细胞免疫 | Cellular immunity | - |
外周血单核细胞分离液 | Peripheral blood monocyte isolate | - |
YAP | YAP | - |
细菌感染 | Bacterial infection | - |
凋亡相关 | Apoptosis-related | - |
抑制效果 | Inhibitory effect | - |
Pierce | Pierce | - |
SepMateTM管 | SepMateTM tube | - |
磷酸化ERK | Phosphorylated ERK | - |
不同量 | Different quantities | - |
炎症性肠病 | Inflammatory bowel disease | - |
测序 | Sequencing | - |
人外周血 | Human peripheral blood | - |
清液 | Clear liquid | - |
外周血单核细胞 | Peripheral blood monocyte | - |
单核细胞 | Monocyte; monocyte | - |
慢病毒载体 | Lentiviral vector | - |
测序结果 | Sequencing result | - |
RNAiMAX | RNAiMAX | - |
质粒转染 | Plasmid transfection | - |
基因编辑技术 | Gene editing technique | - |
医科大学 | Medical University | - |
ChamQ | ChamQ | - |
细胞系 | Cell line | - |
感染方法 | Infection methods | - |
细胞分离 | Cell isolation | - |
脯氨酸 | Proline | - |
及其他 | And others | - |
免疫治疗 | Immunotherapy | - |
调控元件 | Regulatory element | - |
下降时 | When descending | - |
PE | PE | - |
免疫疾病 | Immune disease | - |
编辑技术 | Editing technique | - |
更准确 | More accurate | - |
数据差异分析 | Data variance analysis | - |
基因表达 | Gene expression | - |
差异分析 | Variance analysis | - |
研究发现 | The findings | - |
blotting法 | Blotting method | - |
疏水 | Hydrophobic | - |
嘌呤霉素 | Puromycin | - |
RPMI | RPMI | - |
mRNA | MRNA | - |
LPS诱导基因 | LPS-induced gene | - |
病毒感染 | Viral infection | - |
SYBR | SYBR | - |
嵌合抗原 | Chimeric antigen | - |
shRNA | ShRNA | - |
抗凝采血管 | Anticoagulant vessel harvesting | - |
区段 | Section | - |
抑制作用 | Inhibitory effect | - |
单核细胞系 | Monocyte cell line | - |
上皮细胞 | Epithelial cell | - |
细胞染色 | Cell staining | - |
细胞培养板 | Cell culture plate | - |
如图所示 | As shown in the figure | - |
病原体感染 | Pathogen infection | - |
ELISA试剂盒 | ELISA kit | - |
水溶解 | Water dissolution | - |
人单核细胞 | Human monocyte | - |
试剂盒 | Kit | - |
革兰阴性菌 | Gram-negative bacteria | - |
检查点 | Checkpoint | - |
人白介素 | Human interleukin | - |
病毒肺炎 | Viral pneumonia | - |
流式细胞术 | Flow cytometry | - |
感染细胞 | Infected cells | - |
如图 | As shown in the figure | - |
FITC | FITC | - |
敲减 | Knock down | - |
RNA病毒 | RNA virus | - |
MAP激酶 | MAP kinase | - |
最强 | The strongest | - |
蛋白质印迹法 | Western blot | - |
Vacutainer | Vacutainer | - |
诱导激活 | Induced activation | - |
全培养基 | Whole culture medium | - |
ERK | ERK | - |
细胞固定 | Cell fixation | - |
ELISA | ELISA | - |
悬液 | Suspension | - |
Cytokine | Cytokine | - |
PBS | PBS | - |
类型细胞 | Type cell | - |
定量PCR | Quantitative PCR | - |
κB | ④ B | - |
检测试剂盒 | Detection kit | - |
健康成年人 | Healthy adult | - |
刺激控制 | Stimulus control | - |
对照慢病毒 | Control lentivirus | - |
ΝF | § F | - |
RNA酶 | RNAase | - |
不同大小 | Different sizes | - |
抗原受体T | Antigen receptor T | - |
炎性刺激 | Inflammatory stimulus | - |
具体应用 | Specific application | - |
慢病毒 | Lentiviruses | - |
伦理委员会 | Ethics Committee | - |
TAD | TAD | - |
翻译成 | Translated into | - |
同时加入 | Join at the same time | - |
抗原受体 | Antigen receptor | - |
信号通路 | Signal pathway | - |
RNA | RNA | - |
敲低 | Knock low | - |
作用区域 | Active area | - |
委员会批准 | Approved by the Committee | - |
Gibco | Gibco | - |
胎牛血清 | Fetal bovine serum | - |
亚型 | Subtype | - |
ELISA法 | ELISA method | - |
逆转录 | Reverse transcription | - |
PBMC | PBMC | - |
可溶性细胞 | Soluble cell | - |
白介素 | Interleukin | - |
蛋白含量 | Protein content | - |
转染试剂 | Transfection reagent | - |
趋化因子 | Chemotactic factor | - |
BD | BD | - |
Grand | Grand | - |
供血者 | Blood Donor | - |
全身性感染 | Systemic infection | - |
实验结果表明 | The experimental results show that | - |
风湿性关节炎 | Rheumatoid arthritis | - |
gRNA | GRNA | - |
培养箱 | Incubator | - |
具体方法 | Specific methods | - |
纤维细胞 | Fibroblasts | - |
抗体标记 | Antibody labeling | - |
外周血 | Peripheral blood | - |
脂多糖 | Lipopolysaccharide | - |
Biological | Biological | - |
对照组 | Control group | - |
危及生命 | Life-threatening | - |
细胞因子释放综合征 | Cytokine release syndrome | - |
二氧化碳培养箱 | Carbon dioxide incubator | - |
流式细胞术 | Flow cytometry | - |
western | Western | - |
培养上清液 | Culture supernatant | - |
炎症疾病 | Inflammatory disease | - |
人外周血单核细胞 | Human peripheral blood monocyte | - |
炎性因子 | Inflammatory factor | - |
FBS | FBS | - |
guideRNA | GuideRNA | - |
siRNA | SiRNA | - |
KD | KD | - |
yes | Yes | - |
细胞因子 | Cytokines | - |
细胞培养基 | Cell culture medium | - |
正义链 | Justice chain | - |
无转染试剂 | Transfection-free reagent | - |
精氨酸酶 | Arginase | - |
Island | Island | - |
BI | BI | - |
控制组 | Control Group | - |
破膜 | Rupture of membrane | - |
转录因子 | Transcription factor | - |
短肽 | Short peptide | - |
培养基中 | In a medium | - |
导致翻译 | Resulting in translation | - |
坏死因子 | Necrosis factor | - |
抑制剂 | Inhibitor | - |
炎症性肠炎 | Inflammatory enteritis | - |
Lipsky | Lipsky | - |
电转染法 | Electrophoretic transfection | - |
antibody | Antibody | - |
反义链 | Antisense chain | - |
关节滑膜细胞 | Articular synovial cell | - |
引物 | Primer | - |
PCR | PCR | - |
提前终止 | Premature termination | - |
FACSVerse | FACSVerse | - |
抗人 | Anti-human | - |
书面同意 | Written consent | - |
明显差异 | Significant difference | - |
μg/ml | μ g/ml | - |
完全培养基 | Complete medium | - |
siRNA | SiRNA | - |
HiScript | HiScript | - |
免疫性疾病 | Immune disease | - |
实验结果 | Experimental results | - |
血单核细胞 | Blood monocyte | - |
TNF | TNF | - |
肝素钠 | Heparin sodium | - |
抑制凋亡 | Inhibition of apoptosis | - |
显著增强 | Significantly enhanced | - |
无钙镁 | Calcium-free magnesium | - |
肽段 | Peptide fragment | - |
慢病毒感染细胞 | Lentiviral infected cell | - |
聚凝胺 | Polycondensation amine | - |
突变蛋白 | Mutant protein | - |
细胞培养上清液 | Cell culture supernatant | - |
信使RNA | Messenger RNA | - |
实时荧光定量 | Real-time fluorescence quantification | - |
新冠 | COVID-19 | - |
细胞增殖 | Cell proliferation | - |
滑膜细胞 | Synovial cell | - |
细胞培养 | Cell culture | - |
cDNA | CDNA | - |
Life | Life | - |
ΝF-κB | F-Ⅵ B | - |
CAR-T | CAR-T | - |
信号负性调控元件 | Signal negative regulating element | - |
提取及 | Extraction and | - |
片段肽 | Fragment peptide | - |
穿透 | Penetration | - |
DNA酶 | DNase | - |
PRD | PRD | - |
慢性炎症 | Chronic inflammation | - |
肿瘤坏死因子 | Tumor necrosis factor | - |
非配对T | Unpaired T | - |
IBD | IBD | - |
Trizol | Trizol | - |
Industries | Industries | - |
转染 | Transfection | - |
表达水平 | Expression level | - |
荧光定量PCR | Fluorescence quantitative PCR | - |
质粒 | Plasmid | - |
自身免疫性疾病 | Autoimmune disease | - |
人体细胞 | Human somatic cell | - |
先进行活细胞 | Start with live cell | - |
LPS | LPS | - |
细胞裂解液 | Cell lysate | - |
脯氨酸富集区 | Proline-rich region | - |
细胞悬液 | Cell suspension | - |
Stem | Stem | - |
第二天 | The next day | - |
结果显示 | The results show that | - |
Lymphoprep | Lymphoprep | - |
诱导基因 | Inducible gene | - |
小分子肽 | Small molecule peptide | - |
数据显示 | Data Display | - |
逆转录 | Reverse transcription | - |
参考文献 | References | - |
蛋白转染试剂 | Protein transfection reagent | - |
细胞密度 | Cell density | - |
用电转染法 | Electrophoretic transfection | - |
小时后 | Hours later | - |
Storm | Storm | - |
两段 | Two paragraphs | - |
诺唯赞 | Nuoweizan | - |
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